Mononuclear Co(II) and Mn(II) complexes Framework Based on Schiff base ligand: Designing, Synthesis, Structural elucidation, Efficient DNA Binding and Cleavage Activity

Raju Ashokan; Rangappan Rajavel

Volume : IV, Issue : XI, November - 2014

Mononuclear Co(II) and Mn(II) complexes Framework Based on Schiff base ligand: Designing, Synthesis, Structural elucidation, Efficient DNA Binding and Cleavage Activity

Raju Ashokan, Rangappan Rajavel

Abstract :

A group of combinations which have more importance in biological studies, biochemistry and also medical applications are Schiff base complexes. They have been considered by the chemists. Schiff base ligand was provided by means of condensation of o&ndash;phenylenediammine, 2&ndash;amino 4&ndash;cholorophenol with 1, 10&ndash;phenanthroline in absolute ethanol solvent with reflux method. Then the complexes of transition metals Co(II) and Mn(II) with the ligand to being determined synthesized mononuclear Schiff base metal complexes and using elemental analyses, molar conductance, magnetic susceptibility, IR, UV&ndash;Vis spectral data and H1NMR studies. The elemental analysis of the complexes confine to the stoichiometry of the type ML1L2. The possible geometries of metal complexes were evaluated using 3D molecular modelling picture. The binding properties of metal complexes with DNA have been investigated by electronic absorption spectra showing that the complexes have the ability of interaction with DNA by intercalative mode. All the metal complexes cleave the pBR322 DNA in presence of H2O2