Morphology and osmotic fragility in Wistar rat erythrocytes after zinc deficiency and supplementation

Pooja Sharma; Dr. Neena Nair; Deepa Kumari; R.S.Bedwal

Volume : VI, Issue : X, October - 2016

Morphology and osmotic fragility in Wistar rat erythrocytes after zinc deficiency and supplementation

Pooja Sharma, Dr. Neena Nair, Deepa Kumari, R. S. Bedwal

Abstract :

Deficiency of zinc affects the cell memane permeability. The purpose of the study was to assess the effect on erythrocyte morphology and osmotic fragility after 4 and 6 weeks of zinc deficiency and subsequent repletion for a period of 4 weeks. Morphology was adversely affected which enhanced after 6 weeks of zinc deficiency. Moreover, the osmotic fragility which is an indicator of oxidative stress on erythrocytes enhanced wherein 50% was observed at 0.48% (4ZD), 0.60% (6ZD), 0.35% (4ZD–S) and 0.50% (6ZD–S). Supplementation of zinc for 4 weeks did show favorable changes indicating that change in zinc status could lead to loss of memane architecture with enhanced osmotic fragility