Volume : IV, Issue : III, March - 2014

MOSQUITO–LARVICIDAL, ANTI–BACTERIAL AND ANTI–FUNGAL PROPERTIES OF NOVEL 2, 4–DISUBSTITUTED–[1, 3] – THIAZOLES

Mr Prakash Anil Castelino, Dr Jagadeesh Prasad Dasappa, Dr Prashantha Naik, Mr Sharath Chandra K. , Ms Anusha Kumari G. Y.

Abstract :

A series of novel hydrazones of 2, 4–disubstituted–[1, 3] – thiazole (5) were prepared by the reaction of thiosemicabazone (3) with different substituted phenacyl halides (4) in the presence of dimethylformamide as a solvent. The requisite thiosemicarbazone (3) was synthesized by the treatment of thiosemicabazide (1) with 2, 4–dichloro–5–fluroacetophenone (2) in presence of catalytic amount of mineral acid.  All the novel compounds were confirmed and characterized by elemental analysis, FT–IR, 1H–NMR,      13C–NMR and Mass spectra and were subjected to anti–bacterial, anti–fungal activity studies and also screened for mosquito–larvicidal activitiy studies against two pathogenic vectors namely; Anopheles stephenesis (malaria vector) and C. tritaeniorhynchus (Japanese encephalitis). Among the novel 2, 4–disubstituted [1, 3]– thiazoles (5a– 5o), the compounds 2–{2–[1–(2, 4–dichloro–5–fluorophenyl) ethylidene] hydrazinyl}–4–(4–fluorophenyl)–[1, 3]–thiazole (5j)  and 2–{2–[1–(2, 4–dichloro–5–fluorophenyl) ethylidene] hydrazinyl}–4–(4–nitrophenyl) –[1, 3] –thiazole (5m) exhibit anti–bacterial and anti–fungal properties. Though the mosquito–larvicidal activity is low among the novel derivatives, yet,  4–(4–omophenyl)–2–{2–[1–(2, 4–dichloro–5–fluorophenyl) ethylidene] hydrazinyl} –[1, 3]–thiazole (5i)  and 2–{2–[1–(2, 4–dichloro–5–fluorophenyl) ethylidene] hydrazinyl}–4–(4–fluorophenyl)–[1, 3]– thiazole (5j) may be recommended as  mosquito larvicidal agents for further studies

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Prakash Anil Castelino, Jagadeesh Prasad Dasappa, Prashantha Naik, Sharath Chandra K., Anusha Kumari G. Y., MOSQUITO-LARVICIDAL, ANTI-BACTERIAL AND ANTI-FUNGAL PROPERTIES OF NOVEL 2, 4-DISUBSTITUTED-[1, 3]‾THIAZOLES Indian Journal of Applied Research, Vol.IV, Issue. III


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