Volume : IX, Issue : V, May - 2019

MRI Evaluation of Peritumoral Brain Edema in Meningiomas– Correlation with Aquaporins 1,4 and 9

Dr Vivek Sharma, Dr. Roma Rai

Abstract :

Aim: To correlate presence of Peritumoral Brain Edema in cases of meningiomas with aquaporins 1, 4 and 9 in the tumoral ain tissue. Settings and Design: Cross Sectional Descriptive Study Material and Methods: The study included thirty cases of intracranial meningiomas that were managed at a tertiary care institute. Peritumoral Brain Edema was correlated with expression of Aquaporins 1,4 and 9 using immunochemistry. Statistical analysis used: All calculations were done using the SPSS software version 14.0 for Windows. Results: An approx 64.2 % cases with PTBE expressed AQP1 vis–a–vis only 6.2% cases without PTBE. An approx 85.7 % of cases with PTBE expressed AQP4 vis–a–vis only 6.2% cases without PTBE. AQP 9 expression was noticed in only 3 (10 %) cases out of total 30 cases. Although all these 3 cases had associated PTBE, rest of the 11 cases associated with PTBE did not exhibited expression of AQP9. Conclusion: Expression of aquaporins 1 & 4 is associated with development of peritumoral ain edema in cases of meningiomas. No significant relationship was noted with the expression of aquaporin 9 and peritumoral ain edema. This finding may have an impact on the possible therapeutic target in improving the prognosis of intracranial meningiomas

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Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

MRI EVALUATION OF PERITUMORAL BRAIN EDEMA IN MENINGIOMAS- CORRELATION WITH AQUAPORINS 1,4 AND 9, Dr Vivek Sharma, Dr. Roma Rai INDIAN JOURNAL OF APPLIED RESEARCH : Volume-9 | Issue-5 | May-2019

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