Volume : VII, Issue : VII, July - 2017

MULTIVARIATE ANALYSIS OF ANTIBIOTIC RESISTANCE PATTERN AMONG PSEUDOMONAS ISOLATES CAUSING CSOM

Dr. P. Sankar, Dr. B. Padmini

Abstract :

 Chronic suppurative otitis media is  one of the most common bacterial infection seen in the field of otolaryngology and  the occurrence of otitis media seems to have been rising probably because of prevalence of multidrug–resistant Pseudomonas aeruginosa  in the pathogenesis of otitis media( Jae–Jun Song, MD; Byung Don Lee et al).  Infections caused by pseudomonas aeruginosa are often severe and life threatening and are difficult to treat because of the limited susceptibility to anti microbial agents. (Carmeli; Y; et al ; 1999). The present study was undertaken to detect the group I inducible β – Lactamase production, extended spectrum of β –Lactamases (ESBLs) production and evaluate the synergic effects antibiotic combination   among the MDR pseudomonas aeruginosa isolates.              Out of 43 pseudomonas isolates 23 were multi drug resistant strains. Production of inducible p lactamase was detected (Gencer, etal., 2002; Miles, 1996)  for 20strains; which were susceptible to cephalosporins. By using double disc diffusion test, extended spectrum β–lactamases were detected in 23 Strains. The synerigic effect betweenCephalosporins and aminoglycoside &Cephalosporins and flouroquinolones were detected. It was observed that synergy between aminoglycoside and cephalosporins was found to be maximum 53.5% Plasmid profile analysis was done for all ESBL positive strains and plasmids were detected in all ESBL positive strains.

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Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

Dr. P. SANKAR, Dr. B.PADMINI, MULTIVARIATE ANALYSIS OF ANTIBIOTIC RESISTANCE PATTERN AMONG PSEUDOMONAS ISOLATES CAUSING CSOM, INDIAN JOURNAL OF APPLIED RESEARCH : Volume‾7 | Issue‾7 | July‾2017

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