NEBULIZATION WITH KETAMINE ATTENUATES POST OPERATIVE SORE THROAT AFTER OROTRACHEAL INTUBATION- A RANDOMIZED, PLACEBO CONTROLLED, SINGLE BLIND CLINICAL TRIAL

Dr. Amrita Roy; Dr. Chaitali Biswas; Dr. Dhurjoti Prosad Bhattacharjee

Volume : IX, Issue : XII, December - 2019

NEBULIZATION WITH KETAMINE ATTENUATES POST OPERATIVE SORE THROAT AFTER OROTRACHEAL INTUBATION- A RANDOMIZED, PLACEBO CONTROLLED, SINGLE BLIND CLINICAL TRIAL

Dr. Amrita Roy, Dr. Chaitali Biswas, Dr. Dhurjoti Prosad Bhattacharjee

Abstract :

BACKGROUND:–Tracheal intubation is a foremost cause of trauma to the airway mucosa, resulting in postoperative sore throat with a reported incidence of 21%–65%, causing hindrance in early discharge in day care surgery. AIMS:–In this study we have compared the effectiveness of ketamine nebulization with placebo in attenuating postoperative sore throat after orotracheal intubation and to note any adverse reaction if arises. METHODS:–100 ASA I–II, patients undergoing elective surgery under general anesthesia were randomly divided into 2 groups of 50 each. Group K received Ketamine (50mg in 4 ml saline) nebulization, Group S received saline (5ml) nebulization. Patients were asked to nebulize 15 minutes before induction of anesthesia. Intraoperative Hemodynamic parameters were noted. POST was graded at 0, 2, 8, 12 and 24 hour postoperatively on a four point scale (0–3). RESULTS:– Post–operative sore throat (POST) occurred more frequently in Group S when, compared to Group K, at 0,2,8 12 and 24hour and significantly more patients suffered severe POST in Group S at 8, 12 and 24 hour compared with Group K. CONCLUSION:–Ketamine nebulization significantly reduced the incidence and severity of POST.