Volume : VII, Issue : XI, November - 2017

NEUROPHARMACOLOGICAL BENEFITS WITH ANTICONVULSANT EFFECT OF NEBIVOLOL IN SWISS ALBINO MICE

Dr. Muthukavitha. G, Dr. Ahil . M. S

Abstract :

 Aim & Objective: To evaluate the neuropharmacological benefits along with anticonvulsant activity of Nebivolol in Pentylenetetrazole induced seizure method in swiss albino mice.Materials & Methods:The mice were randomly allocated into four groups of six animals each.       All mice in standard & test groups were given Phenobarbitone30 mg/kg i.p and the test drug Nebivolol (0.25 and 0.5 mg/kg) respectively. Effects on motor function were assessed using an Actophotometer. It was found that there was no impairment in the movement of the animals in both the test groups. After 30 minutes of drug treatment, seizures were induced chemically with PTZ at a dose of 60mg/kg intraperitoneally. The latency to clonic jerks was observed immediately after PTZ injection for a period of 30min.The shortening of transfer latency was observed for the standard & test groups on the second day and it was tabulated. Results: Nebivolol (0.25 and 0.5 mg/kg) has no effect on memory when compared with the control group. No difference was observed in the locomotor activity with nebivolol (0.25 and 0.5 mg/kg) compared with the control group. Nebivolol (0.25 and 0.5 mg/kg) significantly (p < 0.01) prolonged the latency to clonic jerks as compared with the control group. Conclusion: β adrenoceptor antagonist nebivolol has neuropharmacological benefits against  PTZ induced seizures in mice with additional anticonvulsant effect . It may be advantageous in the treatment of epilepsy in hypertensive patients by improving their seizure control.

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Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

Dr. Muthukavitha.G, Dr. Ahil .M.S, NEUROPHARMACOLOGICAL BENEFITS WITH ANTICONVULSANT EFFECT OF NEBIVOLOL IN SWISS ALBINO MICE, INDIAN JOURNAL OF APPLIED RESEARCH : Volume-7 | Issue-11 | November-2017

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