Volume : IX, Issue : I, January - 2019

NEUTROPHIL-LYMPHOCYTE RATIO AS A MARKER OF DISEASE SEVERITY AND EXACERBATION IN COPD

Gokul Prasannan, Kandan Muralidharan, Victor Theophilus Premkumar

Abstract :

CONTEXT: Since the burden of COPD is increasing day by day and is a leading cause of mortality ,it is important to have a prognostic marker for COPD. The well known prognostic marker for COPD is the BODE score,which includes 1)BMI 2)Degree Of Obstruction 3)Dyspnoea Scale 4)Exercise Capacity. Since the calculation Of BODE score is cumbersome and is not possible in sickpatients, it is important to have a simple prognostic marker like Neutrophil Lymphocyte Ratio(NLR) which can be easily obtained from a routine complete blood count which correlates well with that of BODE score AIM OF THE STUDY: To assess whether Neutrophil–to–Lymphocyte ratio can be used to assess the severity of disease by compå it with BODE score in COPD.  To assess whether the Neutrophil Lymphocyte ratio is higher in COPD exacerbation compared to patients with stable COPD. SETTINGS AND DESIGN: Analytical Cross–sectional study MATERIALS AND METHODS : The study is to be conducted among 80 patients which includes 30 patients who attend the emergency department of Gov.Rajaji Hospital,Madurai in a state of COPD Acute exacerbation and 50 Stable COPD patients who attend the OPD for followup. STATISTICALANALYSIS : Data analysis was done with statistical software SPSS.16 software and Sigma Stat 3.5 version . Using this software, mean, standard deviation and p–value were calculated through One way ANOVA, Chi–square test .P– value of < 0.05 was taken as significant. Pearson correlation coefficient was used to find correlation between 2 variables. RESULTS: COPD is more prevalent among smokers and male sex. Low BMI is a risk factor for severe disease. NLR correlated with the severity of air flow obstruction . NLR has a positive correlation with mMRC scale. NLR correlated inversely with 6–minute walk distance.Thus,NLR correlated inversely with BMI,FEV1%,6–minute walk distance and has a positive correlation with mMRC scale. NLR correlated with the disease severity as it has positive correlation with BODE score. NLR was significantly higher in COPD exacerbation compared to patients with stable COPD CONCLUSIONS: NLR correlates well with the disease severity in stable COPD as compared to BODE score. So, it should be used as a routine prognostic marker of mortality in all patients with COPD . NLR can be used as a marker of COPD exacerbations.

Keywords :

Since the burden of COPD is increasing day by day and is a leading cause of mortality    it is important to have a prognostic marker for COPD. The well known prognostic marker for COPD is the BODE score   which includes 1)BMI 2)Degree Of Obstruction 3)Dyspnoea Scale 4)Exercise Capacity. Since the calculation Of BODE score is cumbersome and is not possible in sickpatients   it is important to have a simple prognostic marker like Neutrophil Lymphocyte Ratio(NLR) which can be easily obtained from a routine complete blood count which correlates well with that of BODE score AIM OF THE STUDY To assess whether Neutrophil–to–Lymphocyte ratio can be used to assess the severity of disease by comparing it with BODE score in COPD.  To assess whether the Neutrophil Lymphocyte ratio is higher in COPD exacerbation compared to patients with stable COPD. SETTINGS AND DESIGN Analytical Cross–sectional study MATERIALS AND METHODS The study is to be conducted among 80 patients which includes 30 patients who attend the emergency department of Gov.Rajaji Hospital   Madurai in a state of COPD Acute exacerbation and 50 Stable COPD patients who attend the OPD for followup. STATISTICALANALYSIS Data analysis was done with statistical software SPSS.16 software and Sigma Stat 3.5 version . Using this software   mean   standard deviation and p–value were calculated through One way ANOVA   Chi–square test .P– value of < 0.05 was taken as significant. Pearson correlation coefficient was used to find correlation between 2 variables. RESULTS COPD is more prevalent among smokers and male sex. Low BMI is a risk factor for severe disease. NLR correlated with the severity of air flow obstruction . NLR has a positive correlation with mMRC scale. NLR correlated inversely with 6–minute walk distance.Thus   NLR correlated inversely with BMI   FEV1%   6–minute walk distance and has a positive correlation with mMRC scale. NLR correlated with the disease severity as it has positive correlation with BODE score. NLR was significantly higher in COPD exacerbation compared to patients with stable COPD CONCLUSIONS NLR correlates well with the disease severity in stable COPD as compared to BODE score. So   it should be used as a routine prognostic marker of mortality in all patients with COPD . NLR can be used as a marker of COPD exacerbations Neutrophil–to–Lymphocyte ratio    COPD   

Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

NEUTROPHIL-LYMPHOCYTE RATIO AS A MARKER OF DISEASE SEVERITY AND EXACERBATION IN COPD, Gokul Prasannan, Kandan Muralidharan, Victor Theophilus Premkumar INDIAN JOURNAL OF APPLIED RESEARCH : Volume-9 | Issue-1 | January-2019


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