Volume : VII, Issue : II, February - 2017

NEW IMPROVED PROCESS FOR PREPARATION OF LEVO�CETIRIZINE DIHYDROCHLORIDE AND KEY INTERMEDIATES THEREOF

Yogesh A. Tawar, Rama S. Lokhande, Raju M. Patil, Dilip H. Ner

Abstract :

 A new synthesis for the preparation of optically pure (–)2–[2–(4–[(4–chlorophenyl) phenylmethyl)–1–piperazinyl]ethoxy–aceticacid (Levo–cetirizine) and its pharmaceutically acceptable salts by efficient and cost–effective process for obtaining greatly optically pure Levo–cetirizine in high yield under environmentally acceptable conditions. The present invention relates to a commercially viable, improved process and short route for the preparation of optically pure Levo–cetirizine by optical resolution of its key intermediate (±)1–[(4–chlorophenyl) phenylmethyl] piperazine using O,O‘–Di–p–toluoyl–L–tartaric acid under environmentally acceptable conditions, thereby producing Levo–cetirizine and their pharmaceutical acceptable salts with simultaneous recovery of O,O‘–Di–p–toluoyl–L–tartaric acid.

Keywords :

Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

Yogesh A. Tawar, Rama S. Lokhande, Raju M. Patil, Dilip H. Ner, NEW IMPROVED PROCESS FOR PREPARATION OF LEVO�CETIRIZINE DIHYDROCHLORIDE AND KEY INTERMEDIATES THEREOF, INDIAN JOURNAL OF APPLIED RESEARCH : Volume‾7 | Issue‾2 | February‾2017

Number of Downloads : 727

References :