Volume : VII, Issue : VII, July - 2017

Nitric Oxide and hsCRP in stages of Knee Osteoarthritis

Dr. Nilima J. Gupta, Dr. S. G. Varma, Dr. Sunita Girish

Abstract :

 Background: Osteoarthritis is a leading cause of physical disability and impaired quality of life. There is increasing evidence of production of proinflammatory cytokines and mediators as early features of Osteoarthritis. Nitric oxide is formed by the conversion of arginine to citrulline. Acute phase reactant, C–reactive Protein (CRP) is important in nonspecific host defence against inflammation. Highly Sensitive C–reactive protein (hsCRP) is the most widely used biochemical marker of systemic inflammation. Aim and Objectives: The aim of the study is to measure serum hsCRP and Nitric oxide levels and to correlate between NO and hsCRP. Material and Methods: 60 newly diagnosed, untreated patients of knee osteoarthritis were selected, 30 each from early and late disease. 30 age and sex matched controls were selected. Levels of hsCRP and NO were estimated by standard methods. Results: There was highly significant rise in hsCRP and NO value in early and late knee OA patients as compared to controls. The rise in hsCRP value was significantly high in late knee OA patients, while the rise in NO value was significantly high in early knee OA. There is mild positive correlation between hsCRP and NO in early knee OA while negative correlation in late knee OA. Conclusion: Higher serum hsCRP concentrations in late knee OA indicate association with severity and progression of disease. Higher NO levels in early OA suggesting its role in disease pathogenesis. High NO levels in early OA may help in early detection and timely treatment. 

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Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

Dr. Nilima J. Gupta, Dr. S.G.Varma, Dr. Sunita Girish, Nitric Oxide and hsCRP in stages of Knee Osteoarthritis, INDIAN JOURNAL OF APPLIED RESEARCH : Volume‾7 | Issue‾7 | July‾2017

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