Numerical Analysis of Indomethacin Release from Polymersome Nanoparticles. Effect of Ethanol Content

Rumiana Blagoeva; Assen Nedev; Victoria Michailova

Volume : III, Issue : VII, July - 2014

Numerical Analysis of Indomethacin Release from Polymersome Nanoparticles. Effect of Ethanol Content

Rumiana Blagoeva, Assen Nedev, Victoria Michailova

Abstract :

Numerical analysis of indomethacin release from polymersome nanoparticles was performed. In vitro release study was conducted in distilled water containing different ethanol content using dialysis tube method. The recently proposed by the author’s mathematical model of drug release was validated under the obtained experimental results. It was used for establishing the effect of ethanol content in the nanoparticles solution upon drug release. Numerical simulation of indomethacin release was realized within a period of 36 hours in the case of memane presence, as well as when neglecting it.