Obesity and Associated Cardiovascular Morbidity � A Study in a Tertiary Care Hospital of North India

Dr. Ajay Kumar; Dr. B. Kumar; Dr. Vishvanayak; Dr. Sanjeet Kumar Pandit

Volume : VI, Issue : VI, June - 2016

Obesity and Associated Cardiovascular Morbidity � A Study in a Tertiary Care Hospital of North India

Dr. Ajay Kumar, Dr. B. Kumar, Dr. Vishvanayak, Dr. Sanjeet Kumar Pandit

Abstract :

 Obesity is an independent factor implicated in left ventricular (LV) hypertrophy and increased left ventricular mass. Early detection of increased LV mass in obese patients has prognostic and therapeutic implications. Obesity and high BMI is associated with increased cardiovascular morbidity and mortality. A direct effect of isolated obesity on cardiac function is not well established. The study was designed to determine the direct effect of various grades of isolated obesity on echocardiographic indices of systolic and diastolic left ventricular function. Two Hundred obese and 25 normal weight, personnel without any other pathological condition were studied. Group I (n=25) consisted of subjects with normal weight and body mass index (BMI <25kg/m2), Group II (n=100) of overweight subjects (BMI 25–29.9 kg/m2) and Group III (n=100) of obese subjects (BMI >30 kg/m2). Echocardiographic indices of systolic and diastolic function were obtained and dysfunction was assumed when at least two values differed by ≥ 2 SD from the normal weight group. Ejection fraction, fractional shortening were increased (p<0.05) in Group II and III. Left ventricular dimensions were increased (p< 0.001) but relative wall thickness was unchanged. Systolic dysfunction was not observed in any of the obese patients. The mitral valve pressure half time (p< 0.01), left atrial diameter (p < 0.01) and the deceleration time were increased (p< 0.01) in obese subjects, while other diastolic variables were unchanged. No difference were found between obesity subgroups. Subclinical diastolic dysfunction was more prevalent among obese subjects. BMI correlated significantly with indices of left ventricular systolic and diastolic function.