OBSERVATIONAL STUDY OF RESPONSE AND TOXICITY OF CONCURRENT CHEMO RADIOTHERAPY FOLLOWED BY CONSOLIDATION CHEMOTHERAPY IN LOCALLY ADVANCED NON–SMALL CELL LUNG CARCINOMA

Dr Y. Vishnu Vardhan Reddy; Dr M. Radhika Rani; Dr Syed Mustafa Hashmi; Suhas Mareedu

Volume : X, Issue : II, February - 2020

OBSERVATIONAL STUDY OF RESPONSE AND TOXICITY OF CONCURRENT CHEMO RADIOTHERAPY FOLLOWED BY CONSOLIDATION CHEMOTHERAPY IN LOCALLY ADVANCED NON–SMALL CELL LUNG CARCINOMA

Dr Y. Vishnu Vardhan Reddy, Dr M. Radhika Rani, Dr Syed Mustafa Hashmi, Suhas Mareedu

Abstract :

For Non–Small Cell Lung Cancer (NSCLC) simultaneous administration of radiotherapy with chemotherapy (concurrent or concomitant chemoradiation) followed by further chemotherapy (consolidation chemotherapy) has been shown to have better results compared to chemotherapy or radiotherapy alone. This study analysed the efficacy and effects of the same in Stage III NSCLC cases. 30 patients with proven stage III NSCLC who met the inclusion criteria were treated with 6 MV LINAC with MLC (3DCRT Planning). At the completion of concurrent treatment, 15% were CR and 59% were PR. At 3 months of follow–up, a total of nearly 70% patients responded to the treatment. The adverse effects studied included Esophagitis, Pneumonitis, Neutropenia, Thrombocytopenia and Leukopenia for a 3 month follow up period. The results obtained in our study support the observation that concurrent/consolidation chemoradiation with platinum containing regimens are superior to radiotherapy alone in terms of overall survival, disease–free survival and local control.