Volume : VIII, Issue : I, January - 2018

Obstetric cholestasis : A Review Article

Dr. V. Hemavathy, Gini Jancy Mohan

Abstract :

 

Abstract

Obstetric cholestasis is a rare condition which occurs during the last trimester of pregnancy. The condition does not usually pose a serious risk for the mother ‘s long term health, but it may cause severe complications for the infant like pre mature birth , still birth, meconium aspiration etc. Cholestasis happens when the liver cannot excrete bile properly in to the duodenum and as a result the bile  gets deposited under the skin . It is thought that pregnancy hormones, and especially the additional estrogen, may  affect the proper functioning of the gallbladder and the liver.  The most prominent symptom is itching over the palms of hands and soles of the feet often becomes worse during the night other common symptoms are dark urine, light coloured feces, jaundice. Cholestasis is diagnosed when the total bile acids (TBA) or serum bile acids are measured at 10 micromol/L and above . Close monitoring of the mother and fetal wellbeing is mandatory to avoid complications. Regular maternal blood test, USG, NST should be assessed.  Urodeoxycholic acid, is a drug of choice to relieve itching and increase bile flow, tropical ointments are also useful and also vitamin K supplements are suggested because patients with cholestasis  will have low  levels of vitamin K, increasing the chance of  haemorrhage.

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Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

Dr. V. Hemavathy, Gini Jancy Mohan, Obstetric cholestasis : A Review Article, INDIAN JOURNAL OF APPLIED RESEARCH : Volume-8 | Issue-1 | January-2018

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