Volume : VII, Issue : IX, September - 2017

ORAL CLONIDINE VERSUS ORAL GABAPENTIN AS PREMEDICATION FOR OBTUNDING HEMODYNAMIC RESPONSE TO LARYNGOSCOPY AND TRACHEAL INTUBATION

Dr. Smita Joshi, Dr. Anil Kumar, Dr. Harshi Shah

Abstract :

OBJECTIVES: To evaluate and compare the effect of oral clonidine and oral gabapentin for obtunding hemodynamic response ( HR, SBP, DBP, MAP, RPP ) to laryngoscopy and intubation in normotensive patients having physical status of  Grade–I and Grade–II according to American Society of Anesthesiologists (ASA), scheduled for elective surgery under general anesthesia.

                            To observe the side effects in the above two drugs if any.

 

 

INTRODUCTION: Manipulation of the respiratory tract such as in laryngoscopy and tracheal intubation are associated with hemodynamic and cardiovascular responses consisting of increase in circulating catecholamines, with subsequent increase in heart rate and blood pressure. There is increase in myocardial oxygen demand and dysrhythmias may occur as well. Both Clonidine, an α2 adrenergic agonist and gabapentin which is a GABA_B receptors agonist causes obtunding  of hemodynamic response during laryngoscopy and tracheal intubation.

 

METHOD: A prospective randomized study was done in 60 patients undergoing elective surgeries under standard general anaesthesia was selected randomly and were divided into two groups. Group C – Received 300 µg of clonidine and Group G – Received 900 mg of gabapentin, orally 90 minutes prior to surgery. Parameters such as heart rate (HR), systolic blood pressure (SBP),diastolic blood pressure (DBP),mean arterial pressure (MAP), saturation (Spo₂) and  rate pressure product (RPP) was recorded, before premedication, before induction and during intubation at different time intervals (T0, T1, T3, T5 T10 and T15 minutes). Side effects pertaining to clonidine and gabapentine were recorded post operatively as well.

 

RESULT: In clonidine group the hemodynamic parameters returned below baseline after 5 minutes of  laryngoscopy where as in gabapentine group the hemodynamic parameters remained above baseline throughout surgery after laryngoscopy.

 

CONCLUSION: Oral clonidine 300mcg given 90 minutes prior to surgery was superior to oral gabapentine  900mg in attenuation of hemodynamic response to laryngoscopy and intubation. There was no significant hypotension and adycardia in both the groups.

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Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

Dr. Smita Joshi, Dr. Anil Kumar, Dr. Harshi Shah, ORAL CLONIDINE VERSUS ORAL GABAPENTIN AS PREMEDICATION FOR OBTUNDING HEMODYNAMIC RESPONSE TO LARYNGOSCOPY AND TRACHEAL INTUBATION, INDIAN JOURNAL OF APPLIED RESEARCH : Volume-7 | Issue-9 | September-2017

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