Volume : VI, Issue : II, February - 2016

Oxidative stress in hypertension induced epistaxis – Evaluation of biomarkers in male patients

Drutpal Singh Baghel, Surendra Singh Moupachi, Adesh Patidar

Abstract :

<p>Oxidative stress results from an imbalance between reducing agents and enzymes involved in the removal of free radicals and/or reactive oxygen species. Hypertension is a most common cardiovascular disease in the world. Development of hypertension requires a sub–stained absolute or relative over expansion of blood volume or reduction of the capacitance of the cardiovascular system. Hypertension is associated with epistaxis. The present study comprised 82 hypertensive male patients with epistaxis attended Otorhinolaryngology Department, Gandhi Memorial Hospital, S. S. Medical College, Rewa (Study Group) and 81 ages matched male healthy volunteers (Control Group). The age range was taken from 20–80 years. Antihypertensive drugs effects were observed under supervision of Pharmacology Department, S. S. Medical College, Rewa (M. P.). Blood samples were collected from the patients at the time of admission as well as from individuals of male healthy control groups. Biochemical parameters such as electrolytes, glucose, protein (Total), creatinine, urea, superoxide dismutase (SOD), glutathione reductase (GSH–R), glutathione peroxidase (GSH–Px), catalase and plasma malondialdehyde (P–MDA) were varying significantly in hypertensive patients with epistaxis. Oxidative stress contributes to development of hypertension.</p>

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Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

Drutpal Singh Baghel, Surendra Singh Moupachi, Adesh Padidar Oxidative stress in hypertension induced epistaxis‾Evaluation of biomarkers in male patients Indian Journal of Applied Research, Vol.6, Issue : 2 February 2016

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