Oxidative stress induced by Ethionamide and Para amino salicylic acid cause Amelioration by Piper nigrum (Linn.) in Sprague– Dawley rats.

Gaikwad V. S.; Zodape G. V.

Volume : IX, Issue : V, May - 2019

Oxidative stress induced by Ethionamide and Para amino salicylic acid cause Amelioration by Piper nigrum (Linn.) in Sprague– Dawley rats.

Gaikwad V. S. , Zodape G. V.

Abstract :

The intention of this study is to explore the antioxidant potential of ethanolic seed extract of Piper nigrum (Linn.) (PnS) in Ethionamide (ETH) and Para amino salicylic acid (PAS) induced oxidative stress in rats. Rats, orally administered with ETH 132 mg/kg and Para amino salicylic acid 400 mg/kg ethanolic seed extract of PnS 500 mg/kg for 28 days. Control animals were fed with food pellets and water ad libitum. Assay of anti oxidant enzymes like catalase (CAT), superoxide dismutase (SOD), glutathione (GSH) were determined by taking liver tissue homogenate. In our study we have found the intracellular hepatotoxic marker enzymes showed oxidative stress by decreasing antioxidant levels in drugs treated animals and were controlled when treated with Piper nigrum in single or in combination of both the drugs which confirms the oxidative stress induced by ETH and PAS cause amelioration by Piper nigrum in Sprague– Dawley rats