Volume : IV, Issue : III, March - 2014

Pancreatic ?–Cells Regeneration During the Reversal of Autoimmune Diabetes in Nod Mice.

Takuma Hayashi

Abstract :

Nonobese diabetic (NOD) mice are a model for type 1 diabetes in humans. Treatment of NOD mice with end–stage disease by injection of donor splenocytes and complete Freund‘s adjuvant eliminates autoimmunity and permanently restores normoglycemia. The return of endogenous insulin secretion is accompanied by the reappearance of pancreatic beta–cells (β–cells). Our research group now shows that live donor male or labeled splenocytes administered to diabetic NOD females contain cells that rapidly differentiate into islet and ductal epithelial cells within the pancreas. Treatment with irradiated splenocytes is also followed by pancreatic β–cells regeneration, but at a slower rate. The pancreatic β–cells generated in both instances are persistent, functional, and apparent in all NOD hosts with permanent disease reversal. Such inter–endocrine spontaneous adult cell conversion could be harnessed towards methods of producing pancreatic β–cells for diabetes therapies, either in differentiation settings or in induced regeneration.

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Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

Takuma Hayashi Pancreatic ?-Cells Regeneration During the Reversal of Autoimmune Diabetes in Nod Mice. Indian Journal of Applied Research, Vol.IV, Issue. III

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