PANTHENOL AND SUCCINATE AS MODULATORS OF CHANGES OF REDOX BALANCE AND ENERGY METABOLISM IN THE EXPERIMENTAL MODEL OF PARKINSON‘S DISEASE

Dmitry S. Semenovich; Elena P. Lukiyenko; Oksana V. Titko; Nina P. Kanunnikova

Volume : VIII, Issue : VIII, August - 2018

PANTHENOL AND SUCCINATE AS MODULATORS OF CHANGES OF REDOX BALANCE AND ENERGY METABOLISM IN THE EXPERIMENTAL MODEL OF PARKINSON‘S DISEASE

Dmitry S. Semenovich, Elena P. Lukiyenko, Oksana V. Titko, Nina P. Kanunnikova

Abstract :

We studied changes in oxidative stress parameters, energy metabolism and thiol–disulfide balance in rat blood plasma and ain hemispheres after injections of rothenone (3 mg/kg, ip, 14 days) as a model of Parkinson’s disease. We used D–panthenol and succinate (both 200 mg/kg, per os) as possible modulators of the rotenone–induced damages. We showed that rotenone caused development of oxidative stress, decrease in GSH level and GSH/GSSG ratio, decrease in the protein thiol content and increase in the level of S–glutathionylated proteins in the ain hemispheres. Simultaneously, we observed increase of activities of enzymes of pentose phosphate pathway. We found neuroprotective action of panthenol with succinate in rotenone–induced neurodegeneration. This action is not only to reduce the formation of the products of free radical oxidation, but also to strengthen the activity of the systems supporting the redox balance.