Volume : VII, Issue : VI, June - 2017

Patent Ductus Arteriosus: A Cadaveric Observational Study

Mrudula Chandrupatla, Sunny Yadav, Shabana Sultana

Abstract :

 Patent ductus arteriosus (PDA) is a condition wherein the ductus arteriosus fails to close after birth . Ductus arteriosus is a communication between the descending thoracic aorta and pulmonary artery seen in the fetal life and closes after birth. In a PDA, the vessel does not close and remains "patent" (open), resulting in irregular transmission of blood between the aorta and the pulmonary artery.This condition is frequently diagnosed in infants but in some it may be seen in the later stages of life . In isolated patent ductus arteriosus left to right shunting may be see. The incidence of PDA in term infants is about 1 in 2000 births, accounting for 5 to 10% of all congenital heart disease. The female to male ratio is ∼2:1. Histologically the ductus arteriosus contains more smooth muscle which helps in narrowing of the lumen and shortening . Physiologically the factors which maintain the patency of ductus is exposure to low partial pressure of oxygen , circulating prostaglandins and local nitric oxide production from endothelial cells . The availability of echocardiography has improved the detection of congenital PDA, resulting in earlier treatment. A continuous murmur is heard, located at the upper left sternal border, referred to as a “machinery” murmur. It radiates down the left side of the sternum and into the back, and a thrill may be present. Closure of PDA, by either surgery or transcatheter techniques, can now be achieved safely, resulting in a decrease in the incidence of severe complications of PDA.

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Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

Mrudula Chandrupatla, Sunny Yadav, Shabana sultana, Patent Ductus Arteriosus: A Cadaveric Observational Study, INDIAN JOURNAL OF APPLIED RESEARCH : Volume‾7 | Issue‾6 | June‾2017

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