Persistent hyperinsulinism – hyperinsulinemic hypoglycemia:  Follow up and review of 16 cases

Narayanan.E; Kumutha.J

Volume : VI, Issue : IV, April - 2016

Persistent hyperinsulinism – hyperinsulinemic hypoglycemia: Follow up and review of 16 cases

Narayanan. E, Kumutha. J

Abstract :

Congenital hyperinsulinism (HI) is a condition characterized by unregulated insulin secretion from the pancreatic beta cells in relation to blood glucose concentration and secondary to various genetic disorders 1. HI is a heterogeneous disorder with two main clinically indistinguishable histo pathological lesions: diffuse and focal 2. HIH severity varies from life–threatening hypoglycemia in neonates within the first days of life, which may require a near–total pancreatectomy, to mildly symptomatic hypoglycemia with initial manifestations in adolescence or adulthood, which may be difficult to identify. The aim of treatment is to achieve normoglycemia without ain damage .We report and discuss the clinical and biochemical characteristics, mode of treatment, and neurodevelopmental outcomes in 16 children who were seen between 2002 and 2013 and diagnosed to have HIH.