PHARMACEUTICAL DEVELOPMENT OF ARJUNA KSHEERAPAKA POWDER PREPARED FROM DIFFERENT METHODS & ITS ANALYTICAL EVALUATION

Sinduja. V; Rakesh Salve; Lekshmi Priya; Madhavi Patel

Volume : IX, Issue : VIII, August - 2019

PHARMACEUTICAL DEVELOPMENT OF ARJUNA KSHEERAPAKA POWDER PREPARED FROM DIFFERENT METHODS & ITS ANALYTICAL EVALUATION

Sinduja. V, Rakesh Salve, Lekshmi Priya, Madhavi Patel

Abstract :

Introduction: Ksheerapaka is an extraction method in which both aqueous and lipid soluble extractives are extricated from the pungent and astringent drugs, where milk will perform as chirality compound. Ksheerapaka is prepared by four different methods and it has to be consumed instantly. Hence the Ksheerapaka is developed into powder form by drier method to increase its shelf life. Methodology: The present study is done to realise suitable method for preparation of Arjuna Ksheerapaka and the Ksheerapaka powder, by quantitative and qualitative estimation. Aims & Objectives: 1. To prepare Arjuna Ksheerapaka by using four different methods. 2. To convert Ksheerapaka into powder form by spray drier method. 3. To find out the qualitative analysis for the resultant product. Results: The percentages of powder obtained by the methods are: Method 1 – 5%, Method 2 – 2.39%, Method 3 – 4.025% and Method 4 – 5.66%. High Performance Thin Layer Chromatography (HPTLC) finger printing at 540nm refraction was done to estimate the numbers of chemical constituents obtained unaltered from methods and the results are: Method 1 – 2, Method 2 – 3, Method 3 – 6 & Method 4 – 5. Discussion: Ksheerapaka is preferred for pungent and astringent drugs, to counter their attributes and make them palatable and there are different methods for its preparation. The Ksheerapaka prepared by different methods are converted into powder form and analysed by Physico–chemical parameters and HPTLC. Sharangdhara’s method has higher relevance at 540nm refraction where, 6 chemical constituents from the raw drug were found intact in ksheerapaka powder.