PHARMACOKINETIC INTERACTIONS BETWEEN CONCOMITANTLY ADMINISTERED CARBAMAZEPINE WITH RIVAROXABAN

Y. Karnakar Reddy; T. Rama Mohan Reddy

Volume : VII, Issue : IX, September - 2017

PHARMACOKINETIC INTERACTIONS BETWEEN CONCOMITANTLY ADMINISTERED CARBAMAZEPINE WITH RIVAROXABAN

Y. Karnakar Reddy, T. Rama Mohan Reddy

Abstract :

The present study was aimed to evaluate any possible pharmacokinetic interactions between Carbamazepine and Rivaroxaban. Study was conducted in Male Wistar rats; the treatment was given on day one and day 8 both alone Carbamazepine and Rivaroxaban and concomitantly used both the drugs. The results were showed no significant difference in the t_max of Carbamazepine alone and combination with Rivaroxaban on day 1 and day 8 respectively. These was significant decrease in both c_max and t_maxof Rivaroxaban alone and combination of Carbamazepine on day 1 and day 8 respectively. Carbamazepine combined–gp inducer and strong CYP3A4 inducer, therefore it may induce the metabolism of Rivaroxaban so it reduces the concentrations and increase the elimination rate. Based on the results obtained from kinetic study it was evident that the single dose of Carbamazepine and Rivaroxaban individually and concomitantly treated shows statistically significant interactions in its pharmacokinetic parameters.