Volume : IX, Issue : X, October - 2019

Phase II Trial of Curcumin in Advanced Head and Neck Cancer Treatment

Sunil Saini

Abstract :

Introduction: This study investigates the therapeutic potential of oral curcumin with piperine in the palliative management of advanced squamous cell carcinoma of head and neck region. Methods: 40 patients with advanced, incurable or metastatic squamous cell carcinoma of head and neck region or those who have failed all standard treatment were included in this study without randomization. Patients received capsules of curcumin with piperine (3.6 g/day) for a period of 8 weeks.QOL was assessed using EORTC QLQ–C30 (version 3) & QLQ–H&N35 questionnaires. Results: A significant improvement in global health status, pain, fatigue, constipation and financial difficulty scores was observed at the end of treatment. The study therapy was well tolerated and no grade 3/4 toxicities were observed. Conclusions: The present study indicates the therapeutic potential of curcumin and piperine in the palliative treatment of advance head and neck cancer as a cost–effective substitute.

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Article: Download PDF    DOI : 10.36106/ijar  

Cite This Article:

PHASE II TRIAL OF CURCUMIN IN ADVANCED HEAD AND NECK CANCER TREATMENT, Sunil Saini INDIAN JOURNAL OF APPLIED RESEARCH : Volume-9 | Issue-10 | October-2019

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