Phytochemical and nephroprotective activity of Hibiscus cannabinus against gentamycin induced nephrotoxicity in rats

Dr. Rafia Sultana; Dr. Syed Arshaduddin Ahmed

Volume : VI, Issue : X, October - 2016

Phytochemical and nephroprotective activity of Hibiscus cannabinus against gentamycin induced nephrotoxicity in rats

Dr. Rafia Sultana, Dr. Syed Arshaduddin Ahmed

Abstract :

Protective effect of Hibiscus cannabinus leaves extract on gentamycin induced nephrotoxicity in albino wistar rats were investigated by analyzing various biochemical parameters. Gentamycin induced kidney damage was well manifested by significant increase in renal parameters like serum creatinine, serum uric acid, blood urea nitrogen, serum urea and weight of kidney. The oral administration of ethanolic leaves extract of Hibiscus cannabinus (250mg/kg and 500mg/kg,p.o) along with gentamycin reversed these altered parameters to normal level which indicating the nephroprotective efficacy of Hibiscus cannabinus against gentamycin induced kidney injury. Further extensive studies are required for its potential uses in clinical practice.