Platelet morphology, bleeding time & clotting time in diabetic & healthy females

Mr. Srinivasa Ravi Kiran Suri; Dr. P. Jayanth Kumar

Volume : VIII, Issue : II, February - 2018

Platelet morphology, bleeding time & clotting time in diabetic & healthy females

Mr. Srinivasa Ravi Kiran Suri, Dr. P. Jayanth Kumar

Abstract :

Background: Platelet hyperreactivity in conditions like diabetes mellitus has been considered as evidence for many systemic dysfunctions. Platelets exposure to hyperosmolar solutions may increase platelet reactivity, further hyperglycemia leads to direct osmotic effect. OBJECTIVE: This study is performed to assess the platelets morphology in control & diabetics. MATERIALS & METHODS: This study is performed in Alluri Sita Rama Raju academy of medical sciences (ASRAM), Eluru. Platelet count was performed by REES–ECKER method in dept of physiology, ASRAM. 30 females were considered in each group. Platelet morphology is performed through Thyrocare. Height and weight were measured with the subject in light clothes without shoes and body mass index (BMI) (kg/m2) was calculated. Statistical analysis was done by Microsoft office 2010. Predefined inclusion and exclusion criteria were set for selection of the study group. Results: Platelet Distribution Width, Mean Platelet Volume, Platelet Count, Bleeding time, Clotting Time was found statistically significant. Diabetic patients who are having micro & macro vascular complications, retinopathy and nephropathy were excluded. The patients who are on antibiotics were excluded. Conclusion: There is an increase in MPV, PDW, PC, BT and CT in diabetic females as compared with control. This indicates increase in blood glucose levels may act on insulin receptors on platelets. Increase in platelet count may be an indicator of elevated blood glucose levels & future vascular complications.