Volume : VII, Issue : VIII, August - 2017

PLATELET MORPHOLOGY IN DIABETICS & NORMAL HEALTHY ELDERLY INDIVIDUALS

Dr. B. Syamala Devi, Dr. P. Jayanth Kumar

Abstract :

 BACKGROUND:

Diabetic mellitus is considered to be a prothrombotic state with chronic platelet activation, activation of the coagulation system & decreased fiinolytic potential. A number of studies performed during the past decades have documented several different platelet function alternations in patients with DM.

OBJECTIVE:

This study is performed to assess the platelets morphology in control & diabetics.

MATERIALS & METHODS:

This study is performed in Alluri Sita Rama Raju academy of medical sciences (ASRAM), Eluru. Platelet count was performed by REES–ECKER method in dept of physiology, ASRAM. Platelet morphology is performed through Thyrocare. Height and weight were measured with the subject in light clothes without shoes and body mass index (BMI) (kg/m2) was calculated. Statistical analysis was done by Microsoft office 2010. Predefined inclusion and exclusion criteria were set for selection of the study group.

RESULTS:

We evaluated totally of 60 male persons. The average considered is between 50–60years. We obtained statistically significant results. There is a significant increase in fasting blood glucose, platelet distribution width, mean platelet volume & platelet count in study group people as compared with control.

CONCLUSION:

Factors that contribute directly to greater platelet reactivity include metabolic abnormalities such as hyperglycemia and hyperlipidemia, both insulin resistance (relative insulin deficiency) and absolute insulin deficiency, as well as associated conditions such as oxidative stress, inflammation, and endothelial dysfunction. Change in platelet structure & volume is observed in diabetes mellitus people. Platelet structure & volume should be monitored frequently & proper care should be taken.

Keywords :

Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

Dr. B. Syamala devi, Dr. P. Jayanth Kumar, PLATELET MORPHOLOGY IN DIABETICS & NORMAL HEALTHY ELDERLY INDIVIDUALS, INDIAN JOURNAL OF APPLIED RESEARCH : Volume‾7 | Issue‾8 | August‾2017


Number of Downloads : 240


References :