Volume : V, Issue : IX, September - 2015
Pocythemia – clinico–laboratory profile and management in a resource limiting setting
Dr. Swathy Moorthy, Dr. Mohini Singh, Dr. Vaiera Manigandan
Abstract :
Background: Janus kinase 2 (JAK 2) mutation is a significant factor in the pathogenesis of Polycythemia Rua Vera. It is also known to occur in other chronic myeloproliferative disorders like Essential Thrombocythemia. We studied the frequency of JAK 2 mutation in patients with Polycythemia Rua Vera, compared the clinical and laboratory parameters of patients who were positive and negative for the mutation and management of these patients in a resource limiting setting. Methods: All patients with the diagnosis of Polycythemia Vera (PV) according to the British Committee for Standards in Hematology (BCSH) guidelines were included in the study. Clinical andlaboratory parameters of the patients with PV were evaluated. On arriving at the morphological diagnosis the patients were screened for the presence or absence of JAK 2 mutation and comparison among the two groups were carried out. Results: We studied about 25 patients with Polycythemia Vera over the last two years. The mean age of the cohort group was 56.5±15.5 years. 7 were female patients. On compå the clinical and lab parameters of the patients with JAK 2 positive and patients with JAK 2 negative, we noticed that JAK 2 positive patients were older by 13.8 years, had higher incidence of elevated haemoglobin, total counts and splenomegaly. The occurrence of thrombotic events was higher in JAK2 positive group, similarly was the incidences of splenomegaly. Conclusion: The presence of JAK 2 mutation did increase the incidence of thrombotic events though the presentation was a decade older in these patients. Managing these patients in a resource limiting setting was also highlighted in our study.
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DOI : 10.36106/ijar
Cite This Article:
Dr. Swathy Moorthy, Dr. Mohini Singh, Dr.Vaiera Manigandan Pocythemia‾clinico-laboratory profile and management in a resource limiting setting Indian Journal of Applied Research, Vol.5, Issue : 9 September 2015
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Dr. Swathy Moorthy, Dr. Mohini Singh, Dr.Vaiera Manigandan Pocythemia‾clinico-laboratory profile and management in a resource limiting setting Indian Journal of Applied Research, Vol.5, Issue : 9 September 2015
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