POST OPERATIVE ANALGESIC REQUIREMENT AND ADVERSE EFFECTS OF INTRATHECALLY ADMINISTERED ADJUVANTS MIDAZOLAM AND CLONIDINE WITH BUPIVACAINE

Dr. T.CHANDRA KUMAR; Dr.S.SENTHIL KUMAR

Volume : VIII, Issue : VIII, August - 2018

POST OPERATIVE ANALGESIC REQUIREMENT AND ADVERSE EFFECTS OF INTRATHECALLY ADMINISTERED ADJUVANTS MIDAZOLAM AND CLONIDINE WITH BUPIVACAINE

Dr. T. Chandra Kumar, Dr. S. Senthil Kumar

Abstract :

We conducted a double blinded randomized control study in 60 patients belonging to ASA I and II undergoing elective lower abdominal surgeries. Patients of both sexes ranging between 22 to 65 years of age were included. Our aim was to evaluate the effects of intrathecal midazolam 2mg and clonidine 30 mcg as adjuvant to bupivacaine for hemodynamic stability and postoperative analgesia. Patients were divided randomly using closed cover technique into two groups of 25 each.Group BM received 3ml of 0.5% heavy bupivacaine 0.4ml midazolam (preservative free) and 0.1ml of normal saline. Group BC received 3ml of 0.5% heavy bupivacaine, 0.2ml clonidine and 0.3 ml of normal saline. The total volume of the injected solution was 3.5ml in both groups. adverse effects and post–operative analgesic requirement were noted in both groups. The data collected were analyzed by Chi square test and students’t’ tests. In both groups, no significant changes were observed in respiratory rate, O2 saturation and sedation in our study. Intrathecal Midazolam as an adjuvant to bupivacaine compå to Clonidine resulted in reduced post–operative analgesic requirement and reduced adverse effects