Volume : VII, Issue : XI, November - 2017

Predictors of response to terlipressin plus albumin therapy in hepatorenal syndrome (HRS) type 1

Dr Shanid Abdulsathar

Abstract :

 BACKGROUND AND AIM

Hepatorenal syndrome type1 (HRS1) is rapidly progressive form of renal failure occurring in cirrhosis. Terlipressin plus albumin is effective in reversing type 1 HRS .Since  1/3 to 1/2 of patients respond to treatment , predictors of response and survival would help identify the patients  likely to benefit from treatment .Aim of the study was to find  predictors of response to  terlipressin plus albumin therapy in HRS1 and  survival at 1 month and 3 months.

METHODS

64 adult patients with HRS1 from June 2013 –June 2016  included in this  study. Patients were  treated with terlipressin 1mg IV 6 hourly and IV albumin until creatinine  <1.5 or develops complication /death/maximum upto 14 days. Primary outcome was  reversal of HRS or death and secondary outcome was recurrence of HRS , side effects, transplant free survival at 30 and 90 days.

 

 

RESULTS

Of 64 patients 58 were treated with TAT . 34 patients  (58.2%)  recovered,24 patients (41.38%) not responded. Baseline s. creatinine was predictive of response to treatment (2.88±0.4 Vs 3.95± 1.2 ),P value 0.025. ROC curve with s.creatinine level of 3.25 was associated with sensitivity of 75 % , specificity of 85.7% . There was significant difference in the mean survival of responders and non responders (52 days Vs 7 days)

CONCLUSIONS

Baseline s.creatinine  significantly correlates with HRS treatment response and  there was significant difference in the mean survival of responders and non responders . 

Keywords :

Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

Dr Shanid AbdulSathar, Predictors of response to terlipressin plus albumin therapy in hepatorenal syndrome (HRS) type 1, INDIAN JOURNAL OF APPLIED RESEARCH : Volume-7 | Issue-11 | November-2017

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