Prevalence and Impact of Subclinical Hypothyroidism on Pregnancy–Prospective study From Apex Institute of North India

Dr Neelam Aggarwal; Dr Vanita Suri; Dr Bharti Joshi; Dr Pinaki Dutta; Dr Anil Bhansali; Dr kanya Mukhopadhyay

Volume : IV, Issue : X, October - 2014

Prevalence and Impact of Subclinical Hypothyroidism on Pregnancy–Prospective study From Apex Institute of North India

Dr Neelam Aggarwal, Dr Vanita Suri, Dr Bharti Joshi, Dr Pinaki Dutta, Dr Anil Bhansali, Dr Kanya Mukhopadhyay

Abstract :

Subclinical hypothyroidism is one end of the spectrum of thyroid disorders with reported incidence of 2–5%. The data on prevalence and impact of subclinical hypothyroidism on pregnancy is restricted from north India; therefore we prospectively evaluated cohort of 1791 pregnant women for thyroid dysfunctions in apex institute of north India. Some important findings in this prospective analysis were 1) high prevalence of subclinical hypothyroidism (10.9%) in pregnancy and 59 % of these women had autoimmunity as cause of hypothyroidism. 2) Subclinical hypothyroidism was associated with significant increase in the rate of cesarean section (p=0.001) and neonates born to these women had lower birth weight as compared to neonates of euthyriod women which was statistically significant (p=0.002). Conclusion: Subclinical hypothyroidism has high prevalence in pregnancy in India and is associated with adverse maternal and fetal outcomes