PREVALENCE OF TB CO–INFECTION IN HIV/AIDS – A STUDY IN OSMANIA GENERAL HOSPITAL

R.SIDDESWARI; B.SURYANARAYANA; N.SRINIVASA RAO; T.ABHILASH

Volume : VI, Issue : IV, April - 2016

PREVALENCE OF TB CO–INFECTION IN HIV/AIDS – A STUDY IN OSMANIA GENERAL HOSPITAL

R. Siddeswari, B. Suryanarayana, N. Srinivasa Rao, T. Abhilash

Abstract :

AIM: The present study aims to assess the prevalence of tuberculosis (TB) in patients of HIV/AIDS attending to ART center during the period of 2011–2015, which is the most common opportunistic infection and curable disease. METHODOLOGY: The present study was a retrospective hospital based study in patients with HIV/AIDS and tuberculosis co infection, attending ART Centre, Department of Medicine, Osmania General Hospital between 2011 to 2015. Data was collected from hospital records which include clinical profile, complete blood picture, renal and liver function tests, sputum microscopy, mantoux test, culture sensitivity, chest radiography, CD4 cell count, fine needle aspiration and biopsy, magnetic resonance imaging, computed tomography, and colonoscopy. RESULTS –Total number of HIV/AIDS patients registered at ART center from 2011–2015 were 5,738 .Number of females were n= 2547(44.39%),males were n= 3169 (55.23%),trans gender were n=22(0.383%). Total number of patients on ART were n= 3506(61.1%).Total number of patients who were not on ART (pre–ART) were n=2232(38.9%) . Total number of TB cases detected were n=616(10.73%) [number of males n= 430 , females n= 185, and transgender n=1]. Mean CD4 cell count in males with TB was 196.77cells/cmm3 ,in females with TB n=204.58 /cmm3 and in transgender with TB was n=187/cmm3 (chart1).Out of 1478 HIV/AIDS registered cases in 2011,TB was detected in n=111 patients by the end of 5 years. Among 111 TB cases, in 2011 n=64(4.33 %) patients were detected with TB, in 2012 n= 18(1.22%) patients were TB positive, in 2013 n= 13 (0.88%) were TB positive, in 2014 n=11 (0.74%) were TB positive and in 2015 n=5(0.34%)were found to be TB positive. In 2012, total number of registered patients were n=1368.Of these 162 became TB positive by the end of four years. In 2012, total number of registered patients were n=1368.Of these 162 became TB positive by the end of four years. In 2013, total number of registered patients were n=1256.Of these 175 became TB positive by the end of three years. In 2014, total number of registered patients were n=815.Of these 88 became TB positive by the end of two years. In 2015, total number of registered patients were n=821.Of these 80 became TB positive by the end of one year (Table 2) CONCLUSION: This study shows prevalence of TB cases attending ART center in patients with HIV/AIDS at Osmania General Hospital is 10.73% .Males are commonly affected. Most of them are becoming TB positive by the end first year and the mean cd4 in males 196.77 cells/mm3 and in females 204.58cells/cmm3.Early initiation of ART will improve the immunological status of the patient thereby reducing opportunistic infections including TB.