Prevalence of Thyroid Autoimmunity and Vitamin D Insufficiency in Patients with Thyroid Disorders.

Dr Ravinder Kaur; Prof Rajinder Singh Yadav

Volume : IX, Issue : V, May - 2019

Prevalence of Thyroid Autoimmunity and Vitamin D Insufficiency in Patients with Thyroid Disorders.

Dr Ravinder Kaur, Prof Rajinder Singh Yadav

Abstract :

Background: (Endocrine disorders are on the rise world over. Diseases of thyroid gland are among the most prevalent endocrine disorders in the world, second only to diabetes mellitus.) In India, autoimmune thyroid disorders have been estimated to be the most frequent endocrine disorders. Thyroid diseases are more prevalent in the sub Himalayan region even in post iodination phase. Aim: To assess the prevalence of thyroid autoimmunity and vitamin D insufficiency in patients with thyroid disorders at a tertiary care centre of Himachal Pradesh. Methodology: Study population comprised of patients above 18 years of age, who were advised thyroid function tests by the clinicians on an outpatient basis.. Patients who were critically ill were excluded from the study.Thyroid function tests (T3, T4, TSH) along with anti thyroperoxidase antibody (ATA)was done by chemiluminescence and vitamin D levels were done by ELISA,(Enzyme linked immunosorbent assay) after serum separation of 120 subjects. ATA level >50uIU/ml was taken as positive and Vitamin D <30ng/ml were taken as insufficient. Results: Mean age of study population was 42.48 (± 12.32) years. Forty hypothyroid and forty hyperthyroid and 40 controls were recruited. ATA positivity was reported in 52.5% (63/120) of the samples. 92% (58/63) were found to be Vitamin D deficient among ATA positives. There was a statistically significant positive association between thyroid autoimmunity and D deficiency (OR=14.8, p value=0.00). Conclusion: Intervention studies may be carried out to assess the role of insufficiency of Vitamin D in development of auto immune thyroid disorders.