Volume : VIII, Issue : I, January - 2018

Prevalence of thyroid dysfunction in women with infertility

Dr. P. Sudha Padmasri, Swarupa R Didla

Abstract :

 

Human conception and pregnancy is both a vulnerable and a robust process. Thyroid hormones have profound effects on reproduction and pregnancy. There is a known association of hyper– and hypothyroidism with menstrual disturbances and decreased fecundity. Women with reproductive failure also have an increased prevalence of organ specific autoimmunity compared to fertile women. The present study was undertaken in 186 women (ages, 28 ± 5 years) with various causes of infertility, and in 100 age–matched (29 ± 5 years) healthy controls with the aim of assessing the prevalence of undisclosed alterations of thyroid function in women with infertility. Female origin of the infertility was diagnosed in 52% of the couples, with specific causes including endometriosis (11%), tubal disease (30%), and ovarian dysfunction (59%). Male infertility represented 38% and idiopathic infertility 17% of the couples. Overall, median thyrotropin (TSH) was significantly higher in patients with infertility compared to controls: 2.0 (0.9) versus 1.4 (0.8) mIU/L. Serum TSH above normal (>4.2 mIU/L) or suppressed TSH (<0.27 mIU/L) levels were not more prevalent in the infertile women than in controls. When thyroid antibodies were positive, both hypothyroidism and hyperthyroidism were more frequent in all women of infertile couples and in the women with a female infertility cause, compared to women in the same groups but without positive TPO–Ab. The present study shows that in infertile women, thyroid dysfunction features are significantly more frequent than in healthy fertile controls.

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Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

Dr. P. Sudha Padmasri, Swarupa R Didla, Prevalence of thyroid dysfunction in women with infertility, INDIAN JOURNAL OF APPLIED RESEARCH : Volume-8 | Issue-1 | January-2018

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