PREVENTION OF RADIATION INDUCED FIBROSIS AND IMPROVING QOL IN HEAD AND NECK CANCER PATIENTS POST SURGERY AND ADJUVANT RADIATION THERAPY WITH OR WITHOUT CONCURRENT CHEMOTHERAPY TREATED WITH GAMMA AND DELTA TOCOTRIENOL (CA PROBRET) AND PENTOXYPHYLLINE

Ashok Kumar; S Bhatnagar; Nilima Mishra

Volume : VIII, Issue : VI, June - 2018

PREVENTION OF RADIATION INDUCED FIBROSIS AND IMPROVING QOL IN HEAD AND NECK CANCER PATIENTS POST SURGERY AND ADJUVANT RADIATION THERAPY WITH OR WITHOUT CONCURRENT CHEMOTHERAPY TREATED WITH GAMMA AND DELTA TOCOTRIENOL (CA PROBRET) AND PENTOXYPHYLLINE

Ashok Kumar, S Bhatnagar, Nilima Mishra

Abstract :

Radiation induced fiosis is a long term adverse effect compromising quality of life. Patients treated with radiation often present with complications like neck fiosis, trismus, facial lymphedema and dysphagia. We evaluated 25 patients of head and neck malignancy treated with surgery followed by radiation +/– chemotherapy. Allpatients were assessed clinically and by mouth opening measured by SK Katharia et al scoring.All patients tolerated treatment well with acceptable hematological toxicity. Out of 25 patients three progressed and were treated with redo surgery and adjuvant palliative chemotherapy. Rest 22 patients completed treatment of six months of gamma and delta tocotrienol and pentoxyphylline.