Volume : VI, Issue : I, January - 2016

Primary Poorly Differentiated Rectal Neuroendocrine Carcinomas: Four case reports and literature review

Burcu Yapar Taskoylu

Abstract :

In this article, we present four cases with primary poor differentiated rectal neuroendocrine carcinomas. The first case was a 34–year–old man with liver metastases at the time of diagnosis. Following six cycles of cisplatin–etoposide therapy, gastrointestinal obstruction developed and he underwent palliative surgery. Brain metastases occurred after surgery. The patient died due to the neurological complications. The second case was a 72–year–old man with intraabdominal lymph nodes at the time of diagnosis. Following three cycles of cisplatin–etoposide therapy, the patient had metastases in the lungs. The third case was a 58–year–old male patient with a bladder and prostate invasion of mass at the time of the diagnosis. Because of the haematuria, carboplatin–etoposide was initiated after a palliative RT. The fourth case, a patient already diagnosed with prostate cancer, was diagnosed with metacron rectal neuroendocrine carcinoma. Radiotherapy and carboplatin–etoposide therapy were given. The patient died after one cycle of therapy due to neutropenic fever and sepsis. All four of our cases had locally advanced or metastatic stage at the time of diagnosis and they were given platinum and etoposide therapy. Treatment protocols of poorly differentiated rectal neuroendocrine carcinomas have yet to be clearly defined. In order to establish treatment protocols for these rarely diagnosed cases, more case studies are needed.

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Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

Burcu Yapar Taskoylu Primary Poorly Differentiated Rectal Neuroendocrine Carcinomas: Four Case Reports and Literature Review Indian Journal of Applied Research, Vol.6, Issue : 1 January 2016

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