Probable Toxic Effect of Methotrexate on Retina using Electroretinography

Ghanbari V; Shushtarian; S.M

Volume : VI, Issue : II, February - 2016

Probable Toxic Effect of Methotrexate on Retina using Electroretinography

Ghanbari V, Shushtarian, S. M

Abstract :

 Aim: Methotrexate is a drug generally prescribed to treat the patients with cancer and autoimmune diseases. The drug has different side effects on different organs of the human body. The aim of present work is to check the probable toxic effect of this drug on retina using Electroretinography. Method: Twenty five patients taking methotrexate for one year, 2.5 mg three times per week were selected for the purpose of present study. Electroretinography was recorded in patients group. Flash ERG was the type of ERG used for this study. Latency (msec) and amplitude (µV) of ERG b wave was measured in each patients. Mean and standard deviation was calculated for patient group. The same procedure was repeated for 25 healthy population as far as visual system was concerned. The results obtained in two groups compared together using SPSS version 13 to search for probable statistically significant difference among case and control groups. Results: The mean latencies/ S.D. and amplitudes/ S.D. of ERG b wave were 47.12±2.90 and 44.68±1.80 and 108.92±16.20 and 116.24±12.30 in case and control groups respectively. The differences between two groups were not statistically significant as far as latency and amplitude of ERG b wave were concerned. Conclusion: From the result of present work it is obvious that retina does not affected in methotrexate consuming patients which will be explained in full paper in detail.