Volume : V, Issue : I, January - 2015

Prolactin and antipsychotics related metabolic disorders

Melinda Kolcsar

Abstract :

Weight gain is the complex result of ambiental, behavioural, genetic and neurohormonal factors. It was observed that efficient antipsychotics near D2 receptorial antagonism have affinity for other receptors, too. Going on paper related differences among the severity of metabolic disturbances induced by typical (selective blockers of D2 receptor) and atypical (non–selective blockers of D2 receptor) antipsychotics, we studied the metabolic effects of some neuroleptics seeking for their correlation with prolactin levels. Our results evidenced that the prevalence of some components of the metabolic syndrome was significantly higher in patients treated with atypical neuroleptics. Insulin resistance stays on the basis of the metabolic syndrome occuring. Elevated prolactinemia seen after administration of both typical and atypical neuroleptics, showed positive correlation with the body mass index and the severity of insulin resistance, pleading for the important role of D2 receptor blocking effects in the appearance of the metabolic syndrome.

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Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

Melinda Kolcsar Prolactin and antipsychotics related metabolic disorders Indian Journal of Applied Research, Vol.5, Issue : 1 January 2015

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