Promising novel urinary protein biomarkers for assessing drug induced acute kidney injury:A Review

ShanmugaSundaram R; Abhirama BR; Gowtham L; Gladys Kalpana; Babitha K Vazhayil; PushpaS; Sudha M; Thiyagarajan T

Volume : III, Issue : VII, July - 2014

Promising novel urinary protein biomarkers for assessing drug induced acute kidney injury:A Review

Shanmugasundaram R, Abhirama Br, Gowtham L, Gladys Kalpana, Babitha K Vazhayil, Pushpas, Sudha M, Thiyagarajan T

Abstract :

Progressionofkidneydiseasefrommildormoderatetoendstagemaybepreventedifitisdetectedataveryearlystage.Sensitivityordiagnosticvaluesofallconventionalbiomarkersarepoor,unreliableandtheirdelayedresponseoftendeliveredfalse–positiveorfalse–negativeresults,whichfinallyleadtoalatedetectionofrenaldamage.Developmentofomicstechnologyleadstotheidentificationofseveralurinaryproteinbiomarkersandtranscriptionalbiomarkerswhichenableearlierdetectionofkidneyinjury.Urinaryproteinbiomarkersshowgoodpredictivepowerandhavegreaterbenefit,becauseofeasyavailabilityofurine.Severalurinaryproteinbiomarkershavebeenidentifiedanddemonstratedsuperiorityindetectingkidneyinjurythanconventionalparameterslikeserumcreatinine(SCr),bloodureanitrogen(BUN),etc.Thesepromisingexperimentalbiomarkersofkidneydamagerequirefurtherconfirmationof their useinroutineclinicaluse