Prospective demographic and clinicohematological profile of chronic lymphocytic leukemia cases in North Indian population

Dr. Ekta Dwivedi; Dr. Suman kumari Pandey

Volume : VIII, Issue : IX, September - 2018

Prospective demographic and clinicohematological profile of chronic lymphocytic leukemia cases in North Indian population

Dr. Ekta Dwivedi, Dr. Suman Kumari Pandey

Abstract :

Introduction: Chronic lymphoid leukemia (CLL) is more common in western countries than Asian population. There are very few studies in Indian population, so the purpose of this study was to determine demographic as well as clinicohematological data of chronic lymphocytic leukemia patients in North India.

Materials and Methods: This was a prospective descriptive type studyconducted on 48 patients with Chronic lymphoproliferative disorders – 26 cases were proved as chronic lymphocytic leukemia on flow cytometry.Detail clinical history & hematological parameters were assessed of CLL patient&data was analyzed using Statistical Package for Social Sciences (SPSS) Version 15.0

Results: The mean age of the patients were 60.85±12.23 (37–80)years, majority were above 60 years of age ( =16/.26 # "0.0" 61.5%). Male to female ratio was 5.5:1. Fever was the most common symptom (61.5%) in our patients followed by weight loss (42.3%) and night sweats (3.8%). Mean value of total leukocyte count ,haemoglobin levels, platelet count were75.4±65.8 x10⁹/l, 10.52±1.94 g/dl, 135.8±77.5 x10⁹/l respectively. Normoytic – normochromic blood picture were in 9 (34.6%) while anisocytic –hypochromic in remaining 17 (65.4%) patients.

Conclusions: 23% of patients were<50 years of age which was earlier in comparison to western scenario–may be due to early age of presentation in our population. Male to female ratio was 5.5:1 showing more tendency towards male population in comparison to western population. Anemic and thrombocytopenic patients with fever as more common presentation.