Protective  effect and antitumor effect  of Phyllanthus niruri extract on DMBA–induced breast cancer in irradiated rats.

Bambang Soeprijanto; Juliati Hood Assegaf

Volume : IV, Issue : V, May - 2014

Protective effect and antitumor effect of Phyllanthus niruri extract on DMBA–induced breast cancer in irradiated rats.

Bambang Soeprijanto, Juliati Hood Assegaf

Abstract :

This study aims to investigate whether the aqueous extract of Phyllanthus niruri administered orally not only contribute to the antitumor effect but also provide a protective effect on east cancer in irradiated rats. An experimental study was carried out on rat with east cancer induced by the 7.12–Dimethylbenz (a) anthracene (DMBA) and then irradiated (6Gy). The research sample were divided randomly in 3 groups (pretest, treatment and control). Each group had 10 rats. The treatment group was given the plant extract orally (250 mg/kg. b. wt). A significant increase in the number of cells expressing Heat Shock Protein 70 (p<0.05) and a significant increase in the number of cancer cells undergo – ing apoptosis (p<0.05) in the treatment group were observed. The result indicated that oral administration of Phyllanthus niruri extract not only increased the antitumor effect but also provided a protective effect on DMBA induced east cancer in irradiated rats. 