Volume : III, Issue : XI, November - 2013

Protective Effect of Curcumin on Mercuric Chloride Induced Oxidative Stress in Rats

Mandava V. Rao, Tapan A. Patel

Abstract :

Curcumin, the yellow pigment in turmeric, is present in the rhizomes of the plant Curcuma longa. Mercury (HgCl2) induces various toxic effects in different organs of the body. The present work was undertaken to evaluate the beneficial effect of curcumin following mercuric chloride induced oxidative stress in rat ain. The antioxidative indices assayed were superoxide dismutase, glutathione peroxidase, glutathione reductase, thiobarbituric acidreactive substances and total –SH groups. Metabolic parameters like total protein, cholesterol, succinate dehydrogenase, adenosine triphosphatase and mercury levels were also measured. Mercury exposure resulted in a significant increase in thiobarbituric acid–reactive substances and mercury levels. Contrarily a decrease in the activities of most of those enzymes, total –SH groups, protein and cholesterol levels were noted. Curcumin administration reduced TBARS and mercury levels, whereas it enhanced the other enzyme activities, total –SH groups, proteins and cholesterol levels comparable to controls. In summary, curcumin administration protects different parts of the ain against mercuric chloride induced neurotoxicity

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Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

Mandava V. Rao, Tapan A. Patel / Protective Effect of Curcumin on Mercuric Chloride Induced Oxidative Stress in Rats / Indian Journal of Applied Research, Vol.3, Issue.11 November 2013

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