Protective Effects of Prunus Avium Extract on 10 Ghz  Induced Damages in the Spleen of Swiss Albino Mice

Faiza Rifat; Archana Sharma; Preeti Srivastava; Shikha Patni; Rashmi Sisodia

Volume : III, Issue : VIII, August - 2013

Protective Effects of Prunus Avium Extract on 10 Ghz Induced Damages in the Spleen of Swiss Albino Mice

Faiza Rifat, Archana Sharma, Preeti Srivastava, Shikha Patni, Rashmi Sisodia

Abstract :

For the present study thirty male Swiss albino mice were selected. They were divided into three groups. Group I: Sham exposed, Group II: 10 GHz microwave exposed, Group III: PAE+MW exposed. After 30 days of treatment the animals were sacrificed to study the histological and biochemical changes in spleen. Microwave exposure resulted in significant reduction of spleen weights. Histopathological examination revealed normal architecture of spleen in sham exposed mice. Only microwave exposure resulted in the architectural disturbances of spleen with fiosis of pulp, irregularly shaped sinusoids and giant cells. Supplementation of PAE before MW exposure resulted in less severe degree of changes. Biochemical analysis showed highly significant (P ≤ 0.01) variations in LPO, GSH and protein levels which could be ameliorated by supplementation of PAE prior to MW exposure. Exposure to 10 GHz leads to histopathological and biochemical alterations in spleen of mice which can be ameliorated by PAE supplementation.