Protective effects of Solanum Lycopercicum fruit extract in cyclophasphamide induced  genotoxicity in germ cells of mice

K. Rudrama Devi; S. Sri Vani; P.P Reddy; Minny Jael.P

Volume : V, Issue : X, October - 2015

Protective effects of Solanum Lycopercicum fruit extract in cyclophasphamide induced genotoxicity in germ cells of mice

K. Rudrama Devi, S. Sri Vani, P. P Reddy, Minny Jael. P

Abstract :

In the present investigation the antimutagenic effects of solanum lucopercicum fruit extract has been evaluated against lead nitrate induced genotoxicity. Single IP administration of solanum lycopercicum fruit extract at various doses i.e. 250, 500 and 1000 mg /kg . When treated individually did not induce chromosomal aberration in germ cells of mice. A single intraperitoneal injection of 50mg/kg of cyclophosphamide induced significant increase in the percentage of chromosomal aberrations in germ cells of mice. However after co administration of three doses of Solanum lycopercicum fruit extract there was a dose dependent decrease in the % of chromosomal aberrations was observed. Thus the results clearly indicate the preventive effects of solanum lycopercicum fruit extract against cyclophosphamide induced genotoxicity in germ cells of mice. Therefore the data indicate that SL fruit extract is a safer dietary component in cancer chemo preventive strategy.