Protective impact of Chelerythrine and DADS against chemically induced hepatocarcinoma

Soumosish Paul; Deblina Misra; Dipanwita Sengupta; Avik Sarkar; Kaustav Dutta Chowdhury; Pradip Kumar Sur; Gobinda Chandra Sadhukhan

Volume : V, Issue : V, May - 2015

Protective impact of Chelerythrine and DADS against chemically induced hepatocarcinoma

Soumosish Paul, Deblina Misra, Dipanwita Sengupta, Avik Sarkar, Kaustav Dutta Chowdhury, Pradip Kumar Sur, Gobinda Chandra Sadhukhan

Abstract :

Study was performed to explore the efficacy of chelerythrine and DADS in combination against P&ndash;DAB&nbsp; and PB induced hepatocellular carcinoma in mice. Five week aged 100 mice were used for the experimental purpose. Animals were divided into five different groups either of sex and each set contained 10 mice. PDAB in combination with PB were administered to develop hepatocarcinoma. 5mg/kg body weight Chelerythrine and&nbsp; 100mg/kg body weight DADS were used as drug in single and as well as in combination to find out their efficacy in&nbsp; the protection of liver tissue against carcinogenic exposure. After 120 days of consecutive experiment different biochemical parameters such as ALT, AST, ALKP, GGT and histopathological tissue analysis were performed. Toxicity analysis was conducted by determining the TBARS content in control animal after drug treatment with stipulated dose and&nbsp; time. Our obsevation revealed that chelerythrine and DADS in combination successfully restored the activities of enzymatic biomarkers and histopathological liver tissue structure similar to control mice.