PROTON MAGNETIC RESONANCE SPECTROSCOPY IN INTRACRANIAL SPACE OCCUPYING LESIONS POTENTIAL ROLE IN IMPROVING DIAGNOSTIC ACCURACY

Navjeet Kaur; Ramanand Gehlot; Kirti Rana Chaturvedy; Preeti Meena

Volume : VII, Issue : VII, July - 2017

PROTON MAGNETIC RESONANCE SPECTROSCOPY IN INTRACRANIAL SPACE OCCUPYING LESIONS POTENTIAL ROLE IN IMPROVING DIAGNOSTIC ACCURACY

Navjeet Kaur, Ramanand Gehlot, Kirti Rana Chaturvedy, Preeti Meena

Abstract :

Proton Magnetic Resonance Spectroscopy(MRS) is a recent neuroimaging advance allowing non–invasive analysis of in vivo metabolites. The study focuses on assessing accuracy of Proton MRS in diagnosis of intracranial space occupying lesions (ICSOLs), differentiating benign from malignant lesions, grading of tumors and compå to conventional imaging in diagnosis and characterization of the same. MRI and MRS (single and multivoxel) were performed on 52 patients selected during one year period, clinically suspected of ICSOLs and followed up by biopsy, surgery or imaging. Spectroscopic findings were evaluated for pathologic spectra. The commonest cause of ICSOLs was gliomas followed by metastases. Mean Cho/ Cr ratio was high in gliomas, metastasis and normal in infections. Cho/Cr and Cho/NAA ratios showed increase with increasing malignancy grade(p<0.05). MRS enables differentiation of malignant from benign lesions with reliable grading of gliomas and hence confidently directs diagnosis and treatment.