RANDOM SPOT URINE PROTEIN / CREATININE RATIO IN THE DIAGNOSIS OF NEPHROTIC SYNDROME IN CHILDREN AGED 2 TO 14 YEARS.

Dr. P. Nagasree; Dr. N L Narasimha Rao; Dr Anusha Deepthi; Dr P. Himabindu

Volume : IX, Issue : VI, June - 2019

RANDOM SPOT URINE PROTEIN / CREATININE RATIO IN THE DIAGNOSIS OF NEPHROTIC SYNDROME IN CHILDREN AGED 2 TO 14 YEARS.

Dr. P. Nagasree, Dr. N L Narasimha Rao, Dr Anusha Deepthi, Dr P. Himabindu

Abstract :

Background: To evaluate the usefulness of urine protein/creatinine ratio (UP/UC) in a random sample of urine as a rapid and reliable test for the quantification of proteinuria. Thus, its accuracy in predicting nephrotic range of proteinuria from other causes of proteinuria in the diagnosis of nephrotic syndrome. Methods: It is a prospective case control study was conducted on 78 children aged 2–14 years over a period of April 1st 2016 to October 31st 2018.who are found to have proteinuria are evaluated clinically and investigated further for diagnosis of cause of proteinuria with relevant necessary investigations by making them into 2 groups. Results: The mean UP/UC in Group 1 is 6.8 that in Group 2 is 0.2 and the difference is significant with a p value of 0.00. The mean 24–hour urine protein in Group 1 is 5327mg/day, that in Group 2 is 177.16mg/day and the difference is significant with a p value of0.00. Conclusion: There is statistically significant correlation between spot urine protein creatinine ratio and 24 hours urine protein both in lower range and upper range of proteinuria. So, 24–hour protein estimation can be replaced by UP/UC ratio in diagnosis of nephrotic syndrome.