REFERENCE INTERVAL FOR THYROID STIMULATING HORMONE ESTIMATED BY INDIRECT METHOD FROM ADULTS ATTENDING A TERTIARY CARE CENTRE IN KERALA

DR. ASHA K. VARGHESE; DR. SHIBU T.S.

Volume : IX, Issue : VI, June - 2019

REFERENCE INTERVAL FOR THYROID STIMULATING HORMONE ESTIMATED BY INDIRECT METHOD FROM ADULTS ATTENDING A TERTIARY CARE CENTRE IN KERALA

Dr. Asha K. Varghese, Dr. Shibu T. S.

Abstract :

In the current study, we have taken one of the most frequently ordered biochemical parameter – TSH level estimation among adults, to check whether the provided kit insert values are applicable for our set of patient population, and also, unlike in earlier available data, if there are any gender differences in same. TSH values were determined in random blood samples from 5709 patients.Non–parametric method was used, along with suitable statistical tools. The reference interval was obtained for the entire data, then for males and females separately, and later compared with the kit insert values. Statistical tests showed inequality between the sub–groups and hence were analysed separately. The RI obtained was 0.322–9.09 μIU/L for the whole data, 0.4475–0.75625 μIU/L for males and 0.31105–9.28 μIU/L for females. The RI differs from kit insert value in upper reference limit and significant gender differences were found in both upper and lower reference limits. The emerging trend calls more extensive studies for resetting our population–specific RI for TSH, comprehensive studies to determine causes for the changing scenario and send the message across to the treating physicians, and to the general population at large