Relationship between maternal metabolism and alterations in the development of the offsprings of diabetic and non-diabetic rats.

Sergio A. Islas-Andrade; Ana Cecilia Polanco-Ponce; Mar�a Cristina Revilla-Monsalve

Volume : VIII, Issue : III, March - 2018

Relationship between maternal metabolism and alterations in the development of the offsprings of diabetic and non-diabetic rats.

Sergio A. Islas Andrade, Ana Cecilia Polanco Ponce, Mar A Cristina Revilla Monsalve

Abstract :

Summary

We used 99 Rats of the Sprague–Dawley strain that weighed between 250 and 350g. They were randomly divided into 4 groups, using diferent dose of STZ. In serum chemistry, diabetic rats showed higher glucose levels than the control (p < 0.001). Cholesterol showed no significant difference between the groups. The levels of triglycerides and VLDL were higher in EI than in EII (P = 0.014), CI (P = 0.005) and CII (p = 0.001). Insulin was lower in EI than in EII (P = 0.004), CI (P = 0.007), and CII (P = 0.018). The percentage of HbA1c was higher in diabetic rats than in non–diabetics (p < 0.001).

The mortality of the rats of the lot EI was greater than those of the rats of the lot EII (P < 0.001). None of the rats EI was able to finish their gestation. Only 23.64% of EI rats had offspring while 86% of the CI and 100% of the CII did so in a normal way (p < 0.001). The EII rats, had longer gestations (20.5 h) than those of the control groups (P = 0.006). There was no difference in the number of oods per litter between the 3 groups. Diabetic rats had higher levels of glycosuria than controls. The gruoup EI had significantly higher levels of ketonuria than rats in the batches EII, CI and CII (p < 0.001). However, EII rats showed higher levels of ketonuria than control rats