Volume : VIII, Issue : III, March - 2018

REPORTING OF ADVERSE DRUG EVENTS TO MONOCLONAL ANTIBODIES IN PATIENTS RECEIVING CHEMOTHERAPY IN A TERTIARY HOSPITAL OF CENTRAL INDIA

Dr. Supriya Sharma, Dr. Varsha Mandloi, Dr. Abhishek Shrivastava, Mr. Arvind Kumar Sharma, Dr. Arun Kumar Shrivastava

Abstract :

 

INTRODUCTION: All drugs have side effects along with their desired effects. Understanding these may help to determine better safety profile. There is limited knowledge regarding the ADRs of Monoclonal Antibodies used for Cancer treatment. AIM: The aim of this study is detection, assessment and reporting of Adverse Drug Reactions in cancer patients undergoing Monoclonal antibody therapy in Indian general patient settings.  MATERIAL AND METHOD: This is hospital based prospective observational study on 30 patients receiving the monoclonal antibodies with or without chemotherapy/radiotherapy for treatment of any type of cancer. Patients were interviewed as per CDSCO adverse drug event reporting form. Data was spread in Microsoft Excel 2010 and analysis was done on SPSS 16.RESULT: Total number of Doses and ADEs observed in Bevacizumab group, Rituximab, Trastuzumab:  45, 30, 2 and 160, 80, 7 respectively. CONCLUSION: The use of monoclonal antibody for cancer therapy is well tolerated and associated with minor adverse reactions that can be managed easily with supportive therapy. 

 

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Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

Dr. Supriya Sharma, Dr.Varsha Mandloi, Dr. Abhishek Shrivastava, Mr. Arvind Kumar Sharma, Dr. Arun Kumar Shrivastava, REPORTING OF ADVERSE DRUG EVENTS TO MONOCLONAL ANTIBODIES IN PATIENTS RECEIVING CHEMOTHERAPY IN A TERTIARY HOSPITAL OF CENTRAL INDIA, INDIAN JOURNAL OF APPLIED RESEARCH : Volume-8 | Issue-3 | March-2018

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